Analysis of the Impact of ROS in Networks Describing Neurodegenerative Diseases

Neurodegenerative diseases such as Parkinson’s or Alzheimer are highly complex in nature and involve various physiological processes. There is clinical evidence that generation of reactive oxygen species (ROS) in dopaminergic neurons induces the apoptosis of mitochondria. Therefore, a kinetic model that describes apoptotic and non- apoptotic states of mitochondria and the regulation of the transition between those two states in neurodegenerative diseases is developed and its dynamic behaviour, in particular the role of reactive oxygen species, is investigated in detail within the proposed project as sketched in fig. 9. The network developed is validated by experimental data so that it reflects accurately the behaviour of neurodegenerative diseases.

Image Neuro-degenerative diseases landscape

A complex three-dimensional landscape depicting stable (A), metastable (B) and unstable (C) state (Huang et al. 2009)

  • Partners: Prof. Balling and Dr. Kolodkin, Luxembourg Centre of Systems Biomedicine
  • Contact: MSc A. Ignaenko